The ChemOffice WebServer is an enterprise server for development and deployment of scientific information applications, including Knowledge Management, Chemical and Biological Informatics, and Scientific Databases

Knowledge Management

• E-Notebook Enterprise and Workgroup streamline the daily record-keeping of research scientists. Notebook pages consist of Excel spreadsheets, Word documents, ChemDraw drawings, and spectral data, and can be searched by text and structure. Oracle or SQL Server support allows organizations to share data, as well as maintain rigorous security and efficient archiving.
• DocManager Enterprise provides ChemFinder for Office functionality for researchers across the enterprise, allowing searches for chemical structures in documents, files, and folders. Document references are stored in a central database and can be searched by text or structure.
• 21CFR11 Compliance is a combination of software (such as E-Notebook and DocManager) and consulting, analysis, and implementation services designed to assist organizations in complying with government regulations. Ongoing monitoring and continued customization also contribute to maintaining compliance in the face of rapidly changing conditions.

Chemical Informatics

• Registration Enterprise is a customizable application that assigns corporate registration numbers for compounds based on each organization’s business rules. It includes duplicate checks with stereochemistry, salt/batch/lot management, data validation, and security. All data structures are accessible for customization using an application programmer’s interface.
• CombiChem Enterprise is a reaction-based library generation program that provides the means to integrate library management with subsequent analytical data on an enterprise-wide basis. Reagents can be selected from many sources including the ChemACX Database, and the resulting library can be analyzed and pruned before committing to experimentation.
• Inventory Enterprise and Workgroup systems can be constructed from CambridgeSoft tools at any level. A personal-productivity system would use ChemFinder for Excel and ChemFinder tools. Enterprise-scalable systems based on ChemOffice WebServer can be combined with Registration and ChemACX solutions for complete management of chemical inventories.

Biological Informatics

• BioAssay Enterprise and Workgroup allow flexible storage, retrieval, and analysis of biological data. Designed for complex lead optimization experiments, the software supports the quick set-up of biological models. Data are presented with easily designed Excel templates, and can be queried by structure or text using ChemFinder.
• BioSAR Enterprise is a catalog-driven data mining and analysis application that presents both form and table views within a single web-based interface. Designed to free researchers from dependence on information technology support resources, it has role-based security that specifies the operations available to administrators, data publishers, and browsers.
• BioViz combines biological data with chemical structure for drug discovery research. From within ChemFinder, BioViz provides graphical representations of structure-related data combined with biological data. Users can search over data and construct scatterplots, hitograms, and other useful data charts. Interactive plots allow selection of subsets of data.

Scientific Databases

• The Merck Index is a database is a structure-searchable encyclopedia of chemicals, drugs, and biologicals. More than 10,000 monographs on single substances and related groups of compounds cover chemical, generic, and brand names; registry numbers; physical data and literature references; structures and stereochemistry; toxicity information; and therapeutic uses.
• ChemACX provides structure searchable chemical sourcing information for 500 catalogs from leading chemical suppliers. ChemSCX offers hundreds of thousands of compounds from suppliers of screening compounds and libraries. The ChemACX database is equipped with a ready-to-use shopping cart system permitting preferred supplier information and installation-specific pricing to be added to ChemACX. Full purchasing authorization and accounting features are included.
• ChemIndex is a directory of over 70,000 common molecules, listing chemical structure, registry numbers, synonyms, physical properties, and links to Internet sources of further information.
• Other scientific databases from leading scientific information suppliers such as Derwent, ISI, and Current Drugs (Thompson), and InfoChem (Springer/Bertlelsman) are also available in ChemFinder format. These databases cover information about patents, reactions, current drug development, and other topics.
• The ChemOffice Browser including ChemDraw Microsoft ActiveX and the ChemDraw and Chem3D Plugins, provides client-side chemical intelligence. These components add chemical intelligence to Microsoft Internet Explorer and Netscape Navigator, enabling client systems to search corporate or WWW databases by structure and text, and analyze 3D models, including molecular surfaces.